Cure CMD teams up with LGMD2iFund to develop antibodies for aDG-RD

The project led by Professor Glenn Morris and Dr. Sue Brown with assistance from Dr. Andrea Brancaccio will use 3 distinct approaches to develop additional antibodies to stain the protein αDG in the muscle membrane.  The currently available antibody to stain αDG is an antibody, called IIH6, to an unknown αDG epitope that recognizes the binding site of laminin alpha 2 to αDG.  Dr. Kevin Campbell has recently donated the hybridoma, or cell clone that makes IIH6 to the Iowa University Hybridoma Bank for general distribution.   The commercially available form of IIH6 can be obtained from Millipore.  While developing antibodies that recognize αDG both for diagnostic purposes and research has been tried without success in past, one hopes that this collaborative multi-faceted approach may yield new antibodies.

This entry was posted in Research News. Bookmark the permalink. Both comments and trackbacks are currently closed.
  • Congenital Muscular Dystrophy

    A group of diseases causing muscle weakness at birth. Several defined genetic mutations cause muscles to break down faster than they can repair or grow. A child with CMD may have various neurological or physical impairments. Some children never gain the ability to walk, while others lose the ability as they grow older. Learn more...

  • Register Now!