Dr. Paolo Bernardi, Italy, presented data showing cyclosporine efficacy in the treatment of 6 patients with Ullrich CMD. Muscle biopsies prior to treatment compared with biopsies one month into treatment showed muscle cell regeneration. Greater effect in children than adults. Mitochondrial Summit Meeting Phoenix, Arizona, cosponsored by FARA and MDA.
Merlini L, AngelinA, Bernardi P, et al. Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies. PNAS 2008 April 1:105 (13):5225-9.
- To see abstract go to: www.pnas.org/cgi/content/abstract/105/13/5225
- To read more about cyclosporine: www.nlm.nih.gov/medlineplus/druginfo/medmaster/a601207.html